{"id":995,"date":"2020-05-04T18:16:48","date_gmt":"2020-05-04T16:16:48","guid":{"rendered":"http:\/\/www.biomaps.universite-paris-saclay.fr\/?page_id=995"},"modified":"2020-05-19T14:42:54","modified_gmt":"2020-05-19T12:42:54","slug":"nouvelles-methodologies-de-radiomarquage","status":"publish","type":"page","link":"https:\/\/www.biomaps.universite-paris-saclay.fr\/index.php\/nouvelles-methodologies-de-radiomarquage\/","title":{"rendered":"Nouvelles m\u00e9thodologies de radiomarquage"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"995\" class=\"elementor elementor-995\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e64ca93 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e64ca93\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a32716e\" data-id=\"a32716e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-78fc547 elementor-widget elementor-widget-text-editor\" data-id=\"78fc547\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p class=\"has-medium-font-size\">Parall\u00e8lement au d\u00e9veloppement de nouveaux traceurs pour l\u2019imagerie TEP, notre \u00e9quipe s\u2019int\u00e9resse \u00e0 la mise au point de m\u00e9thodes innovantes pour le marquage au fluor-18 et au carbone-11 de diff\u00e9rentes structures, des mol\u00e9cules organiques simples aux macromol\u00e9cules biologiques.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-de0d280 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"de0d280\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-630f8b8\" data-id=\"630f8b8\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5c98e9c elementor-widget elementor-widget-heading\" data-id=\"5c98e9c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">M\u00e9thodologie de marquage au Carbone-11<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d4e7f5d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d4e7f5d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-7e9c3de\" data-id=\"7e9c3de\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-09d0b14 elementor-widget elementor-widget-text-editor\" data-id=\"09d0b14\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p class=\"has-medium-font-size\">Les techniques de radiomarquage au carbone-11 reposent dans plus de 95% des cas sur des approches de m\u00e9thylation d\u2019h\u00e9t\u00e9roatomes, limitant la vari\u00e9t\u00e9 de traceurs disponibles pour l\u2019imagerie TEP. De plus, la source primaire de carbone-11, le dioxyde de carbone [<sup>11<\/sup>C]CO<sub>2<\/sub> produit en cyclotron, doit \u00eatre transform\u00e9e en agent m\u00e9thylant ([<sup>11<\/sup>C]CH<sub>3<\/sub>I ou [<sup>11<\/sup>C]CH<sub>3<\/sub>OTf) selon des processus multi-\u00e9tapes longs en regard de la demi-vie de carbone-11 (t<sub>1\/2 <\/sub>= 20.4 minutes) et limitantes pour les rendements de production en radiotraceur. Nous d\u00e9veloppons donc de nouvelles m\u00e9thodes de marquage au carbone-11 innovantes et orthogonales permettant d\u2019incorporer directement le [<sup>11<\/sup>C]CO<sub>2<\/sub> au sein de motifs mol\u00e9culaires complexes pour i) acc\u00e9l\u00e9rer les processus de radiomarquage et ainsi augmenter les rendements de production ii) \u00e9largir l\u2019\u00e9ventail des fonctions chimiques marqu\u00e9es au carbone-11 et donc le panel de radiotraceurs accessibles [1].\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-c98f60b\" data-id=\"c98f60b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0d683e5 elementor-widget elementor-widget-image\" data-id=\"0d683e5\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1475\" height=\"1112\" src=\"https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/05\/Methodo-Figure-1-fran\u00e7ais.jpg\" class=\"attachment-full size-full wp-image-1087\" alt=\"\" srcset=\"https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/05\/Methodo-Figure-1-fran\u00e7ais.jpg 1475w, https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/05\/Methodo-Figure-1-fran\u00e7ais-150x113.jpg 150w, https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/05\/Methodo-Figure-1-fran\u00e7ais-500x377.jpg 500w, https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/05\/Methodo-Figure-1-fran\u00e7ais-768x579.jpg 768w, https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/05\/Methodo-Figure-1-fran\u00e7ais-360x270.jpg 360w\" sizes=\"(max-width: 1475px) 100vw, 1475px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-826394a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"826394a\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-de75979\" data-id=\"de75979\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e57bc57 elementor-widget elementor-widget-heading\" data-id=\"e57bc57\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">M\u00e9thodologie de marquage au Fluor-18<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ab82dd2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ab82dd2\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-aa261fc\" data-id=\"aa261fc\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a143774 elementor-widget elementor-widget-text-editor\" data-id=\"a143774\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p class=\"has-medium-font-size\">Certains h\u00e9t\u00e9rocycles tels que les pyridines poss\u00e8dent une r\u00e9activit\u00e9 int\u00e9ressante pour des r\u00e9actions de substitution nucl\u00e9ophile aromatique, qui sont particuli\u00e8rement favoris\u00e9es sur ce noyau. Nous avons d\u00e9montr\u00e9 qu\u2019un appauvrissement de la densit\u00e9 \u00e9lectronique des pyridines permettait de r\u00e9aliser leur marquage avec du fluor-18 \u00e0 des temp\u00e9ratures bien plus basses que celles habituellement d\u00e9crites pour cette r\u00e9action. Ceci nous a permis de d\u00e9velopper plusieurs applications telles que le marquage direct de peptides ou le marquage sur support solide [2].\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-dab4b40\" data-id=\"dab4b40\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a747a96 elementor-widget elementor-widget-image\" data-id=\"a747a96\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1471\" height=\"565\" src=\"https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/05\/2.jpg\" class=\"attachment-full size-full wp-image-998\" alt=\"\" srcset=\"https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/05\/2.jpg 1471w, https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/05\/2-150x58.jpg 150w, https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/05\/2-500x192.jpg 500w, https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/05\/2-768x295.jpg 768w\" sizes=\"(max-width: 1471px) 100vw, 1471px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0b505b7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0b505b7\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b5a8bda\" data-id=\"b5a8bda\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7195eb9 elementor-widget elementor-widget-spacer\" data-id=\"7195eb9\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6a1c52c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6a1c52c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-7fcccd6\" data-id=\"7fcccd6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c59858e elementor-widget elementor-widget-image\" data-id=\"c59858e\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1228\" height=\"435\" src=\"https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/05\/3.jpg\" class=\"attachment-full size-full wp-image-999\" alt=\"\" srcset=\"https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/05\/3.jpg 1228w, https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/05\/3-150x53.jpg 150w, https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/05\/3-500x177.jpg 500w, https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/05\/3-768x272.jpg 768w\" sizes=\"(max-width: 1228px) 100vw, 1228px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-b804208\" data-id=\"b804208\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e3f3206 elementor-widget elementor-widget-text-editor\" data-id=\"e3f3206\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p class=\"has-medium-font-size\">Nous \u00e9tudions \u00e9galement de nouvelles approches pour la radiofluoration aromatique faisant intervenir des substrats originaux et hautement r\u00e9actifs pour compenser la faible r\u00e9activit\u00e9 de l\u2019ion [<sup>18<\/sup>F]fluorure, dans le but de les appliquer \u00e0 des substrats d\u2019int\u00e9r\u00eat th\u00e9rapeutique particuli\u00e8rement difficiles \u00e0 marquer.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-809e36a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"809e36a\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-10a9649\" data-id=\"10a9649\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bed9ce5 elementor-widget elementor-widget-heading\" data-id=\"bed9ce5\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Marquage d\u2019objets biologiques complexes (des peptides aux prot\u00e9ines) au Fluor-18<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-61da7f9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"61da7f9\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-70de915\" data-id=\"70de915\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5e1dae9 elementor-widget elementor-widget-text-editor\" data-id=\"5e1dae9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p class=\"has-medium-font-size\">Notre \u00e9quipe d\u00e9veloppe diverses m\u00e9thodes pour le radiomarquage de biomol\u00e9cules\u00a0:\n<ul>\n \t<li class=\"has-medium-font-size\"style=\"list-style-type: none;\">\n<ul>\n \t<li>R\u00e9action de SPSAC bioorthogonale entre une biomol\u00e9cule conjugu\u00e9e \u00e0 une sydnone et un alcyne contraint radiomarqu\u00e9 (<sup>18<\/sup>F-DBCO, A). Cette r\u00e9action a \u00e9t\u00e9 mise en application pour le marquage <em>in vivo<\/em> par pr\u00e9ciblage d\u2019un anticorps ciblant les r\u00e9cepteurs EGFR [3].<\/li>\n \t<li>D\u00e9veloppement de diff\u00e9rents groupes prosth\u00e9tiques\u00a0(B), parmi lesquels\u00a0:<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p class=\"has-medium-font-size\" style=\"padding-left: 80px;\">FpyZIDE [4]\n<br>\nFPyMe [5]\n<br>\nFPyKYNE [6]\n<br>\nUn agent de repontage de ponts disulfures<\/p>\n\n<ul>\n \t<li><p class=\"has-medium-font-size\">Marquage enzymatique sp\u00e9cifique de prot\u00e9ines avec une haute activit\u00e9 molaire (LAP-Tag, C)<\/li>\n<\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-8d93774\" data-id=\"8d93774\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b4bf46c elementor-widget elementor-widget-image\" data-id=\"b4bf46c\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"997\" height=\"596\" src=\"https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/05\/4.jpg\" class=\"attachment-full size-full wp-image-1000\" alt=\"\" srcset=\"https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/05\/4.jpg 997w, https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/05\/4-150x90.jpg 150w, https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/05\/4-500x299.jpg 500w, https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/05\/4-768x459.jpg 768w\" sizes=\"(max-width: 997px) 100vw, 997px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d2df9e2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d2df9e2\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0292e74\" data-id=\"0292e74\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b133b6c elementor-widget elementor-widget-heading\" data-id=\"b133b6c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Conception de sondes multimodales et multivalentes<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2418852 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2418852\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-35f6df4\" data-id=\"35f6df4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8d12873 elementor-widget elementor-widget-text-editor\" data-id=\"8d12873\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p class=\"has-medium-font-size\">L\u2019un des projets d\u00e9velopp\u00e9s dans l\u2019\u00e9quipe concerne la mise au point de sondes bimodales pour une application en imagerie TEP et imagerie de fluorescence. Dans cette optique, une mol\u00e9cule pr\u00e9sentant une cyanine et un pr\u00e9curseur de radiofluoration a \u00e9t\u00e9 pr\u00e9par\u00e9 et radiomarqu\u00e9. Gr\u00e2ce \u00e0 la pr\u00e9sence d\u2019un azoture, la sonde bimodale peut ensuite \u00eatre coupl\u00e9e \u00e0 un vecteur de ciblage. Cet objet est \u00e9galement utilis\u00e9 pour la conception de sondes multivalentes, poss\u00e9dant plusieurs entit\u00e9s de ciblages sur une m\u00eame plateforme.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3186ad1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3186ad1\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-bcb5060\" data-id=\"bcb5060\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1fef3f2 elementor-widget elementor-widget-image\" data-id=\"1fef3f2\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"500\" height=\"181\" src=\"https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/05\/5-500x181.jpg\" class=\"attachment-large size-large wp-image-1001\" alt=\"\" srcset=\"https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/05\/5-500x181.jpg 500w, https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/05\/5-150x54.jpg 150w, https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/05\/5-768x278.jpg 768w, https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/05\/5.jpg 1470w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b63d498 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b63d498\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c8beca7\" data-id=\"c8beca7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d7a1a15 elementor-widget elementor-widget-text-editor\" data-id=\"d7a1a15\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>R\u00e9f\u00e9rences<\/h3><p>[1] Del Vecchio A, Caille F, Chevalier A, Loreau O, Horkka K, Halldin C, Schou M, Camus N, Kessler P, Kuhnast B, Taran F, Audisio D. <strong>Late-Stage Isotopic Carbon Labeling of Pharmaceutically Relevant Cyclic Ureas Directly from CO<sub>2<\/sub><\/strong>. (<strong>2018<\/strong>), <em>Angewandt Chemie<\/em>, 57, 9744-9748, <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/anie.201804838\" target=\"_blank\" rel=\"noopener\">doi : 10.1002\/anie.201804838<\/a>.<\/p><p>[2] Richard M , Specklin S , Roche M , Hinnen F , Kuhnast B. <strong>Original synthesis of radiolabeling precursors for batch and on resin one-step\/late-stage radiofluorination of peptides<\/strong>. (<strong>2020<\/strong>), <em>Chem Commun<\/em>, 56, 2507-2510, <a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2020\/cc\/c9cc09434b#!divAbstract\" target=\"_blank\" rel=\"noopener\">doi: 10.1039\/c9cc09434b<\/a><\/p><p>[3] Richard M , Truillet C , Tran VL , Liu H , Porte K , Audisio D , Roche M , Jego B , Cholet S , Fenaille F , Kuhnast B , Taran F , Specklin S. <strong>New fluorine-18 pretargeting PET imaging by bioorthogonal chlorosydnone-cycloalkyne click reaction<\/strong>. (<strong>2019<\/strong>), <em>Chem Commun<\/em>, 55, 10400-10403, <a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2019\/cc\/c9cc05486c#!divAbstract\" target=\"_blank\" rel=\"noopener\">doi: 10.1039\/c9cc05486c<\/a>.<\/p><p>[4] Roche M, Specklin S, Richard M, Hinnen F, G\u00e9n\u00e9rmont K, Kuhnast B. <strong>[<sup>18<\/sup>F]FPyZIDE\u00a0: a versatile prosthetic reagent for the fluorine-18 radiolabeling of biologics <em>via<\/em> copper-catalyzed or strained-promoted alkyne-azide cycloadditions<\/strong>. (<strong>2018<\/strong>), <em>J Label Compds Radiopharm<\/em>, 62, 95-108, <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/jlcr.3701\" target=\"_blank\" rel=\"noopener\">doi: 10.1002\/jlcr.3701<\/a>.<\/p><p>[5] de Bruin B, Kuhnast B, Hinnen F, Yaouancq L, Amessou M, Johannes L, Samson A, Boisgard R, Tavitian B, Doll\u00e9 F. <strong>1-[3-(2-[<sup>18<\/sup>F]fluoropyridin-3-yloxy)propyl]pyrrole-2,5-dione: design, synthesis, and radiosynthesis of a new [<sup>18<\/sup>F]fluoropyridine-based maleimide reagent for the labeling of peptides and proteins<\/strong>. (<strong>2005<\/strong>), <em>Bioconjug Chem<\/em>, 16, 406-20, <a href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/bc0497463\" target=\"_blank\" rel=\"noopener\">doi: 10.1021\/bc0497463<\/a>.<\/p><p>[6] Kuhnast B, Hinnen F, Tavitian B, Doll\u00e9 F. <strong>[<sup>18<\/sup>F]FPyKYNE, a fluoropyridine\u2010based alkyne reagent designed for the fluorine\u201018 labelling of macromolecules using click chemistry<\/strong>. (<strong>2008<\/strong>), <em>J Label Compds Radiopharm<\/em>, 51, 336-342, <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/jlcr.1533\" target=\"_blank\" rel=\"noopener\">doi.org\/10.1002\/jlcr.1533<\/a>.\u00a0<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Parall\u00e8lement au d\u00e9veloppement de nouveaux traceurs pour l\u2019imagerie TEP, notre \u00e9quipe s\u2019int\u00e9resse \u00e0 la mise au point de m\u00e9thodes innovantes pour le marquage au fluor-18 et au carbone-11 de diff\u00e9rentes structures, des mol\u00e9cules organiques simples aux macromol\u00e9cules biologiques. M\u00e9thodologie de marquage au Carbone-11 Les techniques de radiomarquage au carbone-11 reposent dans plus de 95% des [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":615,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"guten_post_layout_featured_media_urls":{"full":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-e1609957375858.png",750,126,false],"thumbnail":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-100x100.png",100,100,true],"medium":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-150x25.png",150,25,true],"medium_large":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-768x129.png",640,108,true],"large":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-500x84.png",500,84,true],"1536x1536":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-1536x257.png",1536,257,true],"2048x2048":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-e1609957375858.png",750,126,false],"guten_post_layout_landscape_large":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-1200x318.png",1200,318,true],"guten_post_layout_portrait_large":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-1200x318.png",1200,318,true],"guten_post_layout_square_large":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-1200x318.png",1200,318,true],"guten_post_layout_landscape":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-600x318.png",600,318,true],"guten_post_layout_portrait":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-600x318.png",600,318,true],"guten_post_layout_square":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-600x318.png",600,318,true],"sciencex-single-team-thumb":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-360x270.png",360,270,true],"sciencex-team-thumbnail":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-263x216.png",263,216,true],"sciencex-event-thumbnail":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-555x318.png",555,318,true],"sciencex-event-gallery-thumb":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-227x168.png",227,168,true],"sciencex-blog-thumb":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-100x80.png",100,80,true]},"_links":{"self":[{"href":"https:\/\/www.biomaps.universite-paris-saclay.fr\/index.php\/wp-json\/wp\/v2\/pages\/995"}],"collection":[{"href":"https:\/\/www.biomaps.universite-paris-saclay.fr\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.biomaps.universite-paris-saclay.fr\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.biomaps.universite-paris-saclay.fr\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.biomaps.universite-paris-saclay.fr\/index.php\/wp-json\/wp\/v2\/comments?post=995"}],"version-history":[{"count":6,"href":"https:\/\/www.biomaps.universite-paris-saclay.fr\/index.php\/wp-json\/wp\/v2\/pages\/995\/revisions"}],"predecessor-version":[{"id":1088,"href":"https:\/\/www.biomaps.universite-paris-saclay.fr\/index.php\/wp-json\/wp\/v2\/pages\/995\/revisions\/1088"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.biomaps.universite-paris-saclay.fr\/index.php\/wp-json\/wp\/v2\/media\/615"}],"wp:attachment":[{"href":"https:\/\/www.biomaps.universite-paris-saclay.fr\/index.php\/wp-json\/wp\/v2\/media?parent=995"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}