{"id":956,"date":"2020-04-30T18:01:06","date_gmt":"2020-04-30T16:01:06","guid":{"rendered":"http:\/\/www.biomaps.universite-paris-saclay.fr\/?page_id=956"},"modified":"2020-05-04T16:04:03","modified_gmt":"2020-05-04T14:04:03","slug":"moyens-techniques","status":"publish","type":"page","link":"https:\/\/www.biomaps.universite-paris-saclay.fr\/index.php\/moyens-techniques\/","title":{"rendered":"Moyens techniques"},"content":{"rendered":"\t\t
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Production des radioisotopes<\/h3>

contact: Julien Varin<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Principe:<\/em>
le cyclotron acc\u00e9l\u00e8re des particules charg\u00e9es via<\/em> un champ \u00e9lectrique puis les guide en utilisant un champ magn\u00e9tique vers leurs cibles\u00a0: \u00ab le noyau de l\u2019atome stable \u00bb. Il se produit alors, du fait de l\u2019\u00e9nergie cin\u00e9tique des particules, une r\u00e9action de transmutation nucl\u00e9aire permettant d\u2019obtenir un atome instable, donc radioactif, qui dans notre cas sera un \u00e9metteur \u03b2+<\/sup> afin de l\u2019utiliser pour l\u2019imagerie TEP.<\/p>

R\u00e9actions de transmutation nucl\u00e9aire<\/em>
14<\/sup>N(p,\u03b1)11<\/sup>C\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 [11<\/sup>C]CO2<\/sub> ou [11<\/sup>C]CH4<\/sub>\u00a0 11<\/sup>C\u00a0\u00a0\u00a0\u00a0\u00a0 20,4 minutes<\/p>

14<\/sup>N(d,n)15<\/sup>O\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 [15<\/sup>O]O2<\/sub> \/H2<\/sub>[15<\/sup>O]O\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 15<\/sup>O\u00a0\u00a0\u00a0\u00a0\u00a0 124 secondes<\/p>

16<\/sup>O(p,\u03b1)13<\/sup>N\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 [13<\/sup>N]NH3<\/sub>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 13<\/sup>N\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 9,96 minutes<\/p>

18<\/sup>O(p,n)18<\/sup>F\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0[18<\/sup>F]F–<\/sup>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 18<\/sup>F\u00a0\u00a0\u00a0\u00a0 109,8 minutes<\/p>

Cyclone 18\/9 (IBA)<\/em>
Acc\u00e9l\u00e9ration des protons ou des deutons \u00e0 une \u00e9nergie respectivement de 18 MeV ou 9 MeV. Champ magn\u00e9tique de 1,9T g\u00e9n\u00e9r\u00e9 par une bobine r\u00e9sistive de cuivre de 2 tonnes. 8 cibles ind\u00e9pendantes: \u00a0production de 18<\/sup>F, 11<\/sup>C ([11<\/sup>C]CO2<\/sub> ou [11<\/sup>C]CH4<\/sub>), 13<\/sup>N et 15<\/sup>O.<\/p>

iMiTRACE (PMB)<\/em>
Acc\u00e9l\u00e9ration des protons \u00e0 une \u00e9nergie de 12 MeV.
Champ magn\u00e9tique de 2,5T (aimant supra).
4 cibles\u00a0: production de 18<\/sup>F, 11<\/sup>C ([11<\/sup>C]CO2<\/sub>).<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Synth\u00e8se organique<\/h3>

contacts: Simon Specklin<\/a>, Myl\u00e8ne Richaud<\/a><\/p>

Laboratoires avec tous les \u00e9quipements standards de chimie organique<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Radiochimie<\/h3>

contacts: Fabien Caill\u00e9<\/a>, Bertrand Kuhnast<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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4 enceintes blind\u00e9es (Lemer Pax) \u00e9quip\u00e9es d\u2019automates de radiosynth\u00e8se TracerLab FxFN, FxN Pro et FxC Pro (GEMS) ou MeI Research (Synthra) pour le d\u00e9veloppement et la fabrication de radiotraceurs.<\/p>

5 enceintes blind\u00e9es (Lemer Pax) pour la R&D en chimie ti\u00e8de.<\/p>

Une boite \u00e0 gants (Medicad)<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Radiopharmacie<\/h3>

contact: Philippe Gervais<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Zone de r\u00e9ception des colis radioactifs.<\/p>

Zone de stockage des mati\u00e8res premi\u00e8res, r\u00e9actifs et mat\u00e9riel st\u00e9rile (classe D)<\/p>

Zone de conditionnement des mati\u00e8res premi\u00e8res (classe C) avec PSM IIB<\/p>

Zone de production (classe C) comprenant 4 enceintes blind\u00e9es (Lemer Pax) \u00e9quip\u00e9es avec des automates de radiosynth\u00e8se All In One (Trasis, x 2,) ou iPHASE C11 Pro2 (iPHASE technologies, x2), une enceinte de r\u00e9partition (classe A) avec 2 pinces de manipulations \u00e0 distances des pr\u00e9parations radiopharmaceutiques marqu\u00e9es au fluor-18 et au carbone-11, 1 enceinte blind\u00e9e pour la fabrication des solutions radiopharmaceutiques marqu\u00e9es au zirconium-89 (classe C), une seconde enceinte de r\u00e9partition (classe A).<\/p>

Zone d\u2019\u00e9chantilloth\u00e8que\/ pharmacoth\u00e8que (classe D)<\/p>

Zone d\u2019exp\u00e9dition des colis radioactifs<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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M\u00e9tabolisme et analyses<\/h3>

contact: Marie-Anne Peyronneau<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Spectrom\u00e9tre de masse LTQ Velos Pro coupl\u00e9 au syst\u00e8me UPLC Ultimate 3000 (Thermo Fischer).<\/p>

\u2022 Analyseur : trappe d\u2019ions double pression
\u2022 Mode d\u2019ionisation : ESI (ou APCI)
\u2022 Logiciels : Excalibur\/Chrom\u00e9leon<\/p>

Applications<\/em>
\u2022 Etudes structurales en MSn : traceurs, m\u00e9dicaments, mol\u00e9cules endog\u00e8nes, interm\u00e9diaires de synth\u00e8se des nouveaux traceurs pour la chimie organique,\u2026
\u2022 Mesure de concentrations traceuses (nM) de petites mol\u00e9cules dans des fluides biologiques et dans les tissus pour le m\u00e9tabolisme, la pharmacocin\u00e9tique et l\u2019enzymologie.<\/p>

Spectrophotom\u00e8tre Lambda UV-VIS 365 (Perkin Elmer)
Chaine HPLC analytique (Waters, Empower) detection UV\/VIS PDA<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Contr\u00f4le qualit\u00e9<\/h3>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Radiochimie<\/em><\/h4>

Contact: Fabien Caill\u00e9<\/a><\/p>

Chaines HPLC analytiques (Waters, Empower)<\/p>

D\u00e9tections\u00a0: UV\/VIS PDA (Waters), radioactive (Berthold), DEDL (Waters), \u00e9lectrochimique (Dionex).<\/p>

Lecteur de plaques radioCCM RITA (Elysia Raytest)<\/p>

Module de contr\u00f4le qualit\u00e9 int\u00e9gr\u00e9 QC1 (QC1)<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Radiopharmacie<\/em><\/h4>\n

\u00a0<\/em>Contact : Christine Coulon<\/a><\/p>\nContr\u00f4le qualit\u00e9 radiophysicochimique\u00a0: <\/em>\n
Chaine HPLC analytique (Perkin Elmer, Empower) avec d\u00e9tection UV\/VIS PDA (Perkin Elmer) et radioactive (Berthold)\n
Lecteurs de plaques radioCCM Bioscan (Canberra)\n
Spectrom\u00e8tre gamma avec d\u00e9tecteur germanium\/lithium (Ortec)\n
Chromatographie gazeuse GC Clarus 580 avec d\u00e9tection FID et avec passeur d\u2019\u00e9chantillons Turbomatrix (Perkin Elmer)\n

\nContr\u00f4le qualit\u00e9 biologique (Classe C)<\/em>\u00a0:\n
PSM IIB (classe A)\n
Incubateurs Bindex (20-25\u00b0C\u00a0; 30-35\u00b0C)\n
Endosafe pour la d\u00e9tection des endotoxines (Charles Rivers)\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Production des radioisotopes contact: Julien Varin Principe:le cyclotron acc\u00e9l\u00e8re des particules charg\u00e9es via un champ \u00e9lectrique puis les guide en utilisant un champ magn\u00e9tique vers leurs cibles\u00a0: \u00ab le noyau de l\u2019atome stable \u00bb. Il se produit alors, du fait de l\u2019\u00e9nergie cin\u00e9tique des particules, une r\u00e9action de transmutation nucl\u00e9aire permettant d\u2019obtenir un atome instable, […]<\/p>\n","protected":false},"author":2,"featured_media":615,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"guten_post_layout_featured_media_urls":{"full":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-e1609957375858.png",750,126,false],"thumbnail":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-100x100.png",100,100,true],"medium":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-150x25.png",150,25,true],"medium_large":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-768x129.png",640,108,true],"large":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-500x84.png",500,84,true],"1536x1536":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-1536x257.png",1536,257,true],"2048x2048":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-e1609957375858.png",750,126,false],"guten_post_layout_landscape_large":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-1200x318.png",1200,318,true],"guten_post_layout_portrait_large":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-1200x318.png",1200,318,true],"guten_post_layout_square_large":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-1200x318.png",1200,318,true],"guten_post_layout_landscape":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-600x318.png",600,318,true],"guten_post_layout_portrait":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-600x318.png",600,318,true],"guten_post_layout_square":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-600x318.png",600,318,true],"sciencex-single-team-thumb":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-360x270.png",360,270,true],"sciencex-team-thumbnail":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-263x216.png",263,216,true],"sciencex-event-thumbnail":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-555x318.png",555,318,true],"sciencex-event-gallery-thumb":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-227x168.png",227,168,true],"sciencex-blog-thumb":["https:\/\/www.biomaps.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/04\/Footer-100x80.png",100,80,true]},"_links":{"self":[{"href":"https:\/\/www.biomaps.universite-paris-saclay.fr\/index.php\/wp-json\/wp\/v2\/pages\/956"}],"collection":[{"href":"https:\/\/www.biomaps.universite-paris-saclay.fr\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.biomaps.universite-paris-saclay.fr\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.biomaps.universite-paris-saclay.fr\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.biomaps.universite-paris-saclay.fr\/index.php\/wp-json\/wp\/v2\/comments?post=956"}],"version-history":[{"count":4,"href":"https:\/\/www.biomaps.universite-paris-saclay.fr\/index.php\/wp-json\/wp\/v2\/pages\/956\/revisions"}],"predecessor-version":[{"id":977,"href":"https:\/\/www.biomaps.universite-paris-saclay.fr\/index.php\/wp-json\/wp\/v2\/pages\/956\/revisions\/977"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.biomaps.universite-paris-saclay.fr\/index.php\/wp-json\/wp\/v2\/media\/615"}],"wp:attachment":[{"href":"https:\/\/www.biomaps.universite-paris-saclay.fr\/index.php\/wp-json\/wp\/v2\/media?parent=956"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}